To study the evacuation characteristics in the Airbus 330 cabin crew under different hatch opening conditions，the Pathfinder software was used to simulate the evacuation characteristics.The evacuation characteristics of personnel were explored in four situations： all cabin doors opened， emergency doors could not be opened， front cabin doors could not be opened， and rear cabin doors could not be opened.The results show that the simulation time for evacuation is 63.3 s when all hatches are open，while 118.3 s when the emergency hatch cannot be opened.The per-unit-time flow of people at No.3，No.4，No.7，and No.8 hatches decreases by 0.09 people，0.2 people 0.09 people，0.04 people respectively.It takes 64s to evacuate people when the front cabin door could not be opened.The number of people evacuated from No.3，No.4，No.5，and No.6 doors are 47，48，52，and 50 respectively，indicating that the failure to open the front cabin door does not have no significant impact on the evacuation time.When the rear cabin door could not be opened，the evacuation time is 112.3s.The time interval from the first person to the last person from the No.3，No.4，No.5 and No.6 doors is 67.7 s，67.6 s，109.9 s and 107.1 s，respectively.This indicates that more passengers in the economy class choose to escape from the hatches No.5 and No.6，which increases the evacuation time.The research results provide a reference for understanding the evacuation characteristics of personnel under different hatch opening conditions.